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KMID : 0881720080230040297
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Journal of Food Hygiene and Safety
2008 Volume.23 No. 4 p.297 ~ p.303
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Effect of Naringin on Lipid Metabolism and Antithrombotic Capacity in Rat
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Kim So-Jeong
Choi Chang-Sun
Park Young-Seok
Park Byung-Kwon
Kim Byeong-Soo
Kim Sang-Ki
Kim Jin
Kim Hyeong-Jin
Kim Soo-Hyun
Lee Seung-Ho
Yoon Seong-Il
Jung Ji-Youn
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Abstract
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Naringin, major citrus flavonoids, has been identified to exert antioxidative, antidiabetic, and lipid lowering effects. In this study, we examined the effect of 0.2 g/kg, 0.5 g/kg naringin supplementation for 3 times/week for 5 weeks on lipid metabolism and antithrombotic capacity in rat. Eighteen five week-old Sprague Dawley(SD) female rats, which had initial body weights of 246 ± 9g, were randomly divided into three groups: Control (non naringin group); Low (0.2 g/kg naringin-supplemented group); High (0.5 g/kg naringin-supplemented group). Three groups of rats were supplemented with three experimental diets for 5 weeks and we investigated antithrombotic capacity before sacrifice. Naringin did not significantly alter the body weight gain, relative organ weight. However, the level of serum triglyceride, serum free fatty acid, serum total lipid and serum glucose levels were significantly lowered compared to those of control. The high group (0.5 g/kg naringin-supplemented group) was showed significantly increased bleeding time compared to control group. These results suggest that naringin supplemental diets reduces the level of hypertension, glycosuria and fatness on the female SD rats, when orally administered below the dosage 0.5 g/kg for 5 weeks.
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KEYWORD
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naringin, antithrombotic capacity, grapefruit, flavonoid, lipid metabolism
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